Silibinin is a modified version of Silymarin and acts as a therapeutic agent for liver related disorders. It is constituted with different types of flavonoids and flavonolignans. Silybum marianum is the milk thistle plant that naturally contains Silymarin and has been a part of traditional folk medicine since early times. Silymarin was widely used for the treatment of gall bladder and liver disorders. In the recent research programmes, silymarin is being studied for its anticancer, anti-inflammatory, anti-diabetic properties and also cardiovascular performance enhancing effects.
Benefits of Silibinin as hepatoprotector:
Lignans are chemical compounds belonging to the category of propyl phenol dimmers unveiling antioxidant and anti-androgenic properties. Flavonoids fall under the class of more than 600 phytopigmentation agents exhibiting anti-inflammatory, cardiotonic and antioxidant effects. Both Silibinin and Silymarin mirror the properties of lignans and flavonoids and thus demonstrate a protective role in liver functioning. One can easily consume Silibinin for liver cell regeneration and accelerate the activity of hepatocytes in secreting regeneration related enzymes via rRNA synthesis. Silibinin is also known to inhibit modifications in symmetric hepatocytes into myofibroblasts that in turn subdues deposition of collagen to prevent liver cirrhosis. The stability and permeability of the cell membrane can also be regulated by this supplement to block the entry of toxins into the liver cells. As an antioxidant agent, Silibinin scavenges free radicals like ROS (reactive oxygen species) to unload the oxygen stress from hepatocytes.
Wider usage of Silibinin:
Apart from the beneficial impacts that Silibinin casts on liver cells, its further effects on other body parts has also been investigated. They can be noted on a cascading order as follows:
- Silibinin works wonder for treating obesity and helps in cutting down extra fat level by increasing the levels of insulin and leptin. These compounds in the sensitive state and potentially work against development of excess fat in adipocytes.
- For patients suffering from Type-II diabetes mellitus, this supplement is a boon as it brings down the levels of triglycerides and total cholesterol (LDL and HDL) in the body.
- Encourages more glucose utilization by cells thereby decreasing the glucose level in blood, achieved by promoting storage of fatty acids.
- The lipid profiles in the blood are improved by Silibinin and this helps to prevent severe heart disorders including coronary artery blockage and atherosclerosis.
- On a final note, Silibinin aims at reducing the risks of cancer by promoting apoptosis (programmed cell death), inhibiting angiogenesis and metastasis via various cell cycle checkpoints.
How to take Silibinin?
The milk thistle supplement or Silibinin is being used since centuries as a part of traditional medications and till date, has not shown any serious side effects. It is a human body friendly supplement and so there are no proper standardised dosage plan suggested for its consumption. One can easily purchase the tablet form of Silibinin and continue to consume safely for 41 months as no negative reports have been noted for that duration of exposure. You can orally consume Silibinin for liver cell regeneration and to enhance other hepato-protective roles of the supplement, provided that you don’t use it with other supplements to cure autoimmune disorders. Any dosage related queries should be consulted with a doctor before consumption to avoid lethal health effects.